Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy

The results of a recently completed Phase III clinical trial suggest that concurrent chemoradiotherapy followed by tecemotide provides superior benefits to Stage IIIa and IIIb non-small cell lung carcinoma patients as compared with sequential chemoradiotherapy followed by tecemotide. These clinical...

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Autores principales: Kao, Chiao-Jung, Wurz, Gregory T, Schröder, Andreas, Wolf, Michael, DeGregorio, Michael W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896473/
https://www.ncbi.nlm.nih.gov/pubmed/24498545
http://dx.doi.org/10.4161/onci.26285
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author Kao, Chiao-Jung
Wurz, Gregory T
Schröder, Andreas
Wolf, Michael
DeGregorio, Michael W
author_facet Kao, Chiao-Jung
Wurz, Gregory T
Schröder, Andreas
Wolf, Michael
DeGregorio, Michael W
author_sort Kao, Chiao-Jung
collection PubMed
description The results of a recently completed Phase III clinical trial suggest that concurrent chemoradiotherapy followed by tecemotide provides superior benefits to Stage IIIa and IIIb non-small cell lung carcinoma patients as compared with sequential chemoradiotherapy followed by tecemotide. These clinical observations will be dissected in a transgenic model of lung cancer that we have recently established (hMUC1.Tg C57BL/6 mice).
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spelling pubmed-38964732014-02-04 Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy Kao, Chiao-Jung Wurz, Gregory T Schröder, Andreas Wolf, Michael DeGregorio, Michael W Oncoimmunology Author's View The results of a recently completed Phase III clinical trial suggest that concurrent chemoradiotherapy followed by tecemotide provides superior benefits to Stage IIIa and IIIb non-small cell lung carcinoma patients as compared with sequential chemoradiotherapy followed by tecemotide. These clinical observations will be dissected in a transgenic model of lung cancer that we have recently established (hMUC1.Tg C57BL/6 mice). Landes Bioscience 2013-10-01 2013-09-12 /pmc/articles/PMC3896473/ /pubmed/24498545 http://dx.doi.org/10.4161/onci.26285 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kao, Chiao-Jung
Wurz, Gregory T
Schröder, Andreas
Wolf, Michael
DeGregorio, Michael W
Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title_full Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title_fullStr Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title_full_unstemmed Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title_short Clarifying the pharmacodynamics of tecemotide (L-BLP25)-based combination therapy
title_sort clarifying the pharmacodynamics of tecemotide (l-blp25)-based combination therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896473/
https://www.ncbi.nlm.nih.gov/pubmed/24498545
http://dx.doi.org/10.4161/onci.26285
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