CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on the scFv. Issues with stability and manufacturability in scFv-based bispecific molecules, however, have been a significant hindrance to their development, particularly for...

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Detalles Bibliográficos
Autores principales: Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896602/
https://www.ncbi.nlm.nih.gov/pubmed/23995618
http://dx.doi.org/10.4161/mabs.26201

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