In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

Here, we describe a fast, easy-to-use, and sensitive method to profile in-depth structural micro-heterogeneity, including intricate N-glycosylation profiles, of monoclonal antibodies at the native intact protein level by means of mass spectrometry using a recently introduced modified Orbitrap Exacti...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosati, Sara, van den Bremer, Ewald TJ, Schuurman, Janine, Parren, Paul WHI, Kamerling, Johannis P, Heck, Albert JR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896605/
https://www.ncbi.nlm.nih.gov/pubmed/23995615
http://dx.doi.org/10.4161/mabs.26282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896605/
https://www.ncbi.nlm.nih.gov/pubmed/23995615
http://dx.doi.org/10.4161/mabs.26282

Ejemplares similares