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Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study
BACKGROUND: Early-pregnancy short sleep duration is predictive of gestational diabetes and preeclampsia; mechanisms for these associations are unknown. Leptin, an adipocyte-derived peptide involved in regulating food intake and energy expenditure, may play a role in these observed associations. Give...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896691/ https://www.ncbi.nlm.nih.gov/pubmed/24405869 http://dx.doi.org/10.1186/1756-0500-7-20 |
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author | Qiu, Chunfang Frederick, Ihunnaya O Sorensen, Tanya K Enquobahrie, Daniel A Williams, Michelle A |
author_facet | Qiu, Chunfang Frederick, Ihunnaya O Sorensen, Tanya K Enquobahrie, Daniel A Williams, Michelle A |
author_sort | Qiu, Chunfang |
collection | PubMed |
description | BACKGROUND: Early-pregnancy short sleep duration is predictive of gestational diabetes and preeclampsia; mechanisms for these associations are unknown. Leptin, an adipocyte-derived peptide involved in regulating food intake and energy expenditure, may play a role in these observed associations. Given inconsistent reports linking short sleep duration with leptin, and absence of studies among pregnant women, we examined the association of maternal sleep duration with plasma leptin in early pregnancy. METHODS: This cross-sectional study included 830 pregnant women. Plasma leptin was measured in samples collected around 13 weeks gestation. Sleep duration was categorized as: ≤5, 6, 7–8 (reference), and ≥9 hours. Differences in leptin concentrations across categories were estimated using linear regression. Analyses were completed for lean and overweight/obese women. RESULTS: Overall, women with long sleep duration had elevated plasma leptin (p-value = 0.04). However, leptin concentrations were not statistically significantly elevated in women with a short sleep duration. There was no association of leptin with sleep duration among lean women. Among overweight/obese women, a U-shaped relation between leptin and sleep duration was observed: Mean leptin was elevated (β = 21.96 ng/ml, P < 0.001) among women reporting ≤5 hour of sleep compared with reference group; and women reporting ≥9 hours of sleep also had elevated leptin (β = 4.29 ng/ml, P = 0.09). CONCLUSIONS: Short sleep duration, and to a lesser extent long sleep duration, were associated with elevated leptin among overweight/obese women. These data add some evidence to help understand mechanistic relationships of sleep duration with pregnancy complications. |
format | Online Article Text |
id | pubmed-3896691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38966912014-01-22 Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study Qiu, Chunfang Frederick, Ihunnaya O Sorensen, Tanya K Enquobahrie, Daniel A Williams, Michelle A BMC Res Notes Research Article BACKGROUND: Early-pregnancy short sleep duration is predictive of gestational diabetes and preeclampsia; mechanisms for these associations are unknown. Leptin, an adipocyte-derived peptide involved in regulating food intake and energy expenditure, may play a role in these observed associations. Given inconsistent reports linking short sleep duration with leptin, and absence of studies among pregnant women, we examined the association of maternal sleep duration with plasma leptin in early pregnancy. METHODS: This cross-sectional study included 830 pregnant women. Plasma leptin was measured in samples collected around 13 weeks gestation. Sleep duration was categorized as: ≤5, 6, 7–8 (reference), and ≥9 hours. Differences in leptin concentrations across categories were estimated using linear regression. Analyses were completed for lean and overweight/obese women. RESULTS: Overall, women with long sleep duration had elevated plasma leptin (p-value = 0.04). However, leptin concentrations were not statistically significantly elevated in women with a short sleep duration. There was no association of leptin with sleep duration among lean women. Among overweight/obese women, a U-shaped relation between leptin and sleep duration was observed: Mean leptin was elevated (β = 21.96 ng/ml, P < 0.001) among women reporting ≤5 hour of sleep compared with reference group; and women reporting ≥9 hours of sleep also had elevated leptin (β = 4.29 ng/ml, P = 0.09). CONCLUSIONS: Short sleep duration, and to a lesser extent long sleep duration, were associated with elevated leptin among overweight/obese women. These data add some evidence to help understand mechanistic relationships of sleep duration with pregnancy complications. BioMed Central 2014-01-09 /pmc/articles/PMC3896691/ /pubmed/24405869 http://dx.doi.org/10.1186/1756-0500-7-20 Text en Copyright © 2014 Qiu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qiu, Chunfang Frederick, Ihunnaya O Sorensen, Tanya K Enquobahrie, Daniel A Williams, Michelle A Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title | Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title_full | Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title_fullStr | Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title_full_unstemmed | Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title_short | Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
title_sort | sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896691/ https://www.ncbi.nlm.nih.gov/pubmed/24405869 http://dx.doi.org/10.1186/1756-0500-7-20 |
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