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Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma

BACKGROUND: It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role in PI3K/AKT pathway. However, the copy number variations (CNVs) of PI3K subunits on gene level remain unknown in DLBCL. Theref...

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Detalles Bibliográficos
Autores principales:	Cui, Wenli, Cai, Ying, Wang, Weige, Liu, Zebing, Wei, Ping, Bi, Rui, Chen, Weixiang, Sun, Menghong, Zhou, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896773/ https://www.ncbi.nlm.nih.gov/pubmed/24418330 http://dx.doi.org/10.1186/1479-5876-12-10

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