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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

BACKGROUND: Immune responses are generally impaired in aged mammals. T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased responses involve altered signaling events associated with the early steps of T ce...

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Detalles Bibliográficos
Autores principales:	Le Page, Aurélie, Fortin, Carl, Garneau, Hugo, Allard, Nancy, Tsvetkova, Krassimira, Tan, Crystal Tze Ying, Larbi, Anis, Dupuis, Gilles, Fülöp, Tamas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896791/ https://www.ncbi.nlm.nih.gov/pubmed/24405902 http://dx.doi.org/10.1186/1478-811X-12-2

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