Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress

Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep t...

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Detalles Bibliográficos
Autores principales: Grønli, Janne, Soulé, Jonathan, Bramham, Clive R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896837/
https://www.ncbi.nlm.nih.gov/pubmed/24478645
http://dx.doi.org/10.3389/fnbeh.2013.00224
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author Grønli, Janne
Soulé, Jonathan
Bramham, Clive R.
author_facet Grønli, Janne
Soulé, Jonathan
Bramham, Clive R.
author_sort Grønli, Janne
collection PubMed
description Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.
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spelling pubmed-38968372014-01-29 Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress Grønli, Janne Soulé, Jonathan Bramham, Clive R. Front Behav Neurosci Neuroscience Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function. Frontiers Media S.A. 2014-01-21 /pmc/articles/PMC3896837/ /pubmed/24478645 http://dx.doi.org/10.3389/fnbeh.2013.00224 Text en Copyright © 2013 Grønli, Soule and Bramham. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Grønli, Janne
Soulé, Jonathan
Bramham, Clive R.
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title_full Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title_fullStr Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title_full_unstemmed Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title_short Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
title_sort sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896837/
https://www.ncbi.nlm.nih.gov/pubmed/24478645
http://dx.doi.org/10.3389/fnbeh.2013.00224
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