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Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro

BACKGROUND: Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic and duodenal homeobox factor (PDX)-1. This study aims to investigate the effects of a novel curcumin derivative (NCD) on JNK signa...

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Detalles Bibliográficos
Autores principales:	Aziz, Mohammed Talaat Abdel, El-Asmar, Mohammed Farid, Rezq, Ameen Mahmoud, Wassef, Mohammed Abdel Aziz, Fouad, Hanan, Roshdy, Nagwa Kamal, Ahmed, Hanan Hosni, Rashed, Laila Ahmed, Sabry, Dina, Taha, Fatma Mohammed, Hassouna, Amira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896850/ https://www.ncbi.nlm.nih.gov/pubmed/24422903 http://dx.doi.org/10.1186/1749-8546-9-3

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