Cargando…
Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack?
BACKGROUND: It may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases. MATERIALS AND METHODS: A total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for ery...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897031/ https://www.ncbi.nlm.nih.gov/pubmed/24516496 |
_version_ | 1782300175314714624 |
---|---|
author | Etemadifar, Masoud Fatemi, Alimohammad Hashemijazi, Hourossadat Kazemizadeh, Amir |
author_facet | Etemadifar, Masoud Fatemi, Alimohammad Hashemijazi, Hourossadat Kazemizadeh, Amir |
author_sort | Etemadifar, Masoud |
collection | PubMed |
description | BACKGROUND: It may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases. MATERIALS AND METHODS: A total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antiβ2-Glycoprotein I antibody (IgG, IgM), anticardiolipin antibody (IgM, IgG), lupus anticoagulant, anti-double strand DNA (anri-ds DNA), antinuclear antibody (ANA), anti-myeloperoxidae (p-ANCA), and anti-Proteinase 3 (C-ANCA). RESULTS: In clinically isolated syndrome group β2-Glycoprotein (IgM) and lupus anti-coagulant were positive in 1.3% of patients whereas ANA was positive in 1.3% and anti-β2-Glycoprotein I (IgM) was positive in 2.5% of control group. No rheumatologic disease was found in objects with positive tests. CONCLUSION: This study shows no specific difference between two groups. |
format | Online Article Text |
id | pubmed-3897031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38970312014-02-10 Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? Etemadifar, Masoud Fatemi, Alimohammad Hashemijazi, Hourossadat Kazemizadeh, Amir J Res Med Sci Short Communication BACKGROUND: It may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases. MATERIALS AND METHODS: A total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antiβ2-Glycoprotein I antibody (IgG, IgM), anticardiolipin antibody (IgM, IgG), lupus anticoagulant, anti-double strand DNA (anri-ds DNA), antinuclear antibody (ANA), anti-myeloperoxidae (p-ANCA), and anti-Proteinase 3 (C-ANCA). RESULTS: In clinically isolated syndrome group β2-Glycoprotein (IgM) and lupus anti-coagulant were positive in 1.3% of patients whereas ANA was positive in 1.3% and anti-β2-Glycoprotein I (IgM) was positive in 2.5% of control group. No rheumatologic disease was found in objects with positive tests. CONCLUSION: This study shows no specific difference between two groups. Medknow Publications & Media Pvt Ltd 2013-07 /pmc/articles/PMC3897031/ /pubmed/24516496 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Etemadifar, Masoud Fatemi, Alimohammad Hashemijazi, Hourossadat Kazemizadeh, Amir Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title | Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title_full | Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title_fullStr | Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title_full_unstemmed | Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title_short | Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
title_sort | is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack? |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897031/ https://www.ncbi.nlm.nih.gov/pubmed/24516496 |
work_keys_str_mv | AT etemadifarmasoud isitnecessarytoperformconnectivetissuedisorderslaboratorytestswhenapatientexperiencesthefirstdemyelinatingattack AT fatemialimohammad isitnecessarytoperformconnectivetissuedisorderslaboratorytestswhenapatientexperiencesthefirstdemyelinatingattack AT hashemijazihourossadat isitnecessarytoperformconnectivetissuedisorderslaboratorytestswhenapatientexperiencesthefirstdemyelinatingattack AT kazemizadehamir isitnecessarytoperformconnectivetissuedisorderslaboratorytestswhenapatientexperiencesthefirstdemyelinatingattack |