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Some Salt with Your Statin, Professor?

We know that clinical trials sponsored by the pharmaceutical industry are likely to exaggerate benefit and minimise harms. But do these biases extend to their sponsorship of non-human animal research? Using systematic review and meta-analysis Bero and colleagues show that, in the case of statins, th...

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Detalles Bibliográficos
Autor principal: Macleod, Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897372/
https://www.ncbi.nlm.nih.gov/pubmed/24465176
http://dx.doi.org/10.1371/journal.pbio.1001768
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author Macleod, Malcolm
author_facet Macleod, Malcolm
author_sort Macleod, Malcolm
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description We know that clinical trials sponsored by the pharmaceutical industry are likely to exaggerate benefit and minimise harms. But do these biases extend to their sponsorship of non-human animal research? Using systematic review and meta-analysis Bero and colleagues show that, in the case of statins, things are a little more complicated. While the conclusions of industry-sponsored studies were indeed more enthusiastic than warranted by their data, the data themselves painted a picture more conservative than was seen in non-industry-sponsored studies. This behaviour is consistent with maximising the return on investment, seeking robust data before embarking on a clinical trial, and, once that investment has been made, making every effort to “prove” that the drug is safe and effective if this is at all credible. The findings suggest that there is something different about industry-sponsored non-human animal research, perhaps reflecting higher standards than is the case elsewhere. Perhaps the academic community can learn something from our colleagues in the commercial sector.
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spelling pubmed-38973722014-01-24 Some Salt with Your Statin, Professor? Macleod, Malcolm PLoS Biol Primer We know that clinical trials sponsored by the pharmaceutical industry are likely to exaggerate benefit and minimise harms. But do these biases extend to their sponsorship of non-human animal research? Using systematic review and meta-analysis Bero and colleagues show that, in the case of statins, things are a little more complicated. While the conclusions of industry-sponsored studies were indeed more enthusiastic than warranted by their data, the data themselves painted a picture more conservative than was seen in non-industry-sponsored studies. This behaviour is consistent with maximising the return on investment, seeking robust data before embarking on a clinical trial, and, once that investment has been made, making every effort to “prove” that the drug is safe and effective if this is at all credible. The findings suggest that there is something different about industry-sponsored non-human animal research, perhaps reflecting higher standards than is the case elsewhere. Perhaps the academic community can learn something from our colleagues in the commercial sector. Public Library of Science 2014-01-21 /pmc/articles/PMC3897372/ /pubmed/24465176 http://dx.doi.org/10.1371/journal.pbio.1001768 Text en © 2014 Malcolm Macleod http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Primer
Macleod, Malcolm
Some Salt with Your Statin, Professor?
title Some Salt with Your Statin, Professor?
title_full Some Salt with Your Statin, Professor?
title_fullStr Some Salt with Your Statin, Professor?
title_full_unstemmed Some Salt with Your Statin, Professor?
title_short Some Salt with Your Statin, Professor?
title_sort some salt with your statin, professor?
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897372/
https://www.ncbi.nlm.nih.gov/pubmed/24465176
http://dx.doi.org/10.1371/journal.pbio.1001768
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