A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese

Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related diseases. We performed genome-wide association studies of mean LTL in 2632 individuals,with a two-stage replication in 3917 individuals from Chinese populations. To further validate our findings, we get the results o...

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Detalles Bibliográficos
Autores principales: Liu, Yun, Cao, Lan, Li, Zhiqiang, Zhou, Daizhan, Liu, Wanqing, Shen, Qin, Wu, Yanting, Zhang, Dan, Hu, Xun, Wang, Ting, Ye, Junyi, Weng, Xiaoling, Zhang, Hong, Zhang, Di, Zhang, Zhou, Liu, Fatao, He, Lin, Shi, Yongyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897378/
https://www.ncbi.nlm.nih.gov/pubmed/24465473
http://dx.doi.org/10.1371/journal.pone.0085043
Descripción
Sumario:Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related diseases. We performed genome-wide association studies of mean LTL in 2632 individuals,with a two-stage replication in 3917 individuals from Chinese populations. To further validate our findings, we get the results of 696 samples from a cohort of European ancestry. We identified two loci associated with LTL that map in telomerase reverse transcriptase (TERT; rs2736100, P = 1.93×10(−5)) on chromosome 5p15.33 and near keratin 80 (KRT80; rs17653722, P = 6.96×10(−6)) on 12q13.13. In Chinese population each C allele of rs2736100 and T allele of rs17653722 was associated with a longer mean telomere length of 0.026 and 0.059 T/S, respectively, equivalent to about 3 and 7 years of average age-related telomere attrition. Our findings provide new insights into telomere regulatory mechanism and even pathogenesis of age-related diseases.

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