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Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes

OBJECTIVE: To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY: A prospective study was performed in...

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Autores principales: Cobo, Teresa, Jacobsson, Bo, Kacerovsky, Marian, Hougaard, David M., Skogstrand, Kristin, Gratacós, Eduard, Palacio, Montse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897420/
https://www.ncbi.nlm.nih.gov/pubmed/24465522
http://dx.doi.org/10.1371/journal.pone.0085277
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author Cobo, Teresa
Jacobsson, Bo
Kacerovsky, Marian
Hougaard, David M.
Skogstrand, Kristin
Gratacós, Eduard
Palacio, Montse
author_facet Cobo, Teresa
Jacobsson, Bo
Kacerovsky, Marian
Hougaard, David M.
Skogstrand, Kristin
Gratacós, Eduard
Palacio, Montse
author_sort Cobo, Teresa
collection PubMed
description OBJECTIVE: To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY: A prospective study was performed in 58 women with PPROM before 34+0 weeks of gestational age. Twenty-six proteins were analyzed by a multiple immunoassay in samples of amniotic fluid, serum, cervix and vagina. Association of an inflammatory response in the invasive and non-invasive samples with MIAC was investigated. RESULTS: The rate of MIAC was 36.2% (21/58). Both amniotic fluid IL-6 and cervical C-reactive protein (CRP) showed to be independent predictors of MIAC. A cut-off level of cervical CRP≥1836 pg/mL showed a detection rate of 75%, false positive rate of 19% and positive and negative predictive values to predict MIAC of 67% and 87%, respectively. There were no independent biomarkers of MIAC either in the serum or vaginal compartment. CONCLUSION: A cervical inflammatory response mediated by CRP was observed in PPROM women with MIAC. Evaluation of serum or vaginal samples did not add valuable information regarding the outcome evaluated.
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spelling pubmed-38974202014-01-24 Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes Cobo, Teresa Jacobsson, Bo Kacerovsky, Marian Hougaard, David M. Skogstrand, Kristin Gratacós, Eduard Palacio, Montse PLoS One Research Article OBJECTIVE: To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY: A prospective study was performed in 58 women with PPROM before 34+0 weeks of gestational age. Twenty-six proteins were analyzed by a multiple immunoassay in samples of amniotic fluid, serum, cervix and vagina. Association of an inflammatory response in the invasive and non-invasive samples with MIAC was investigated. RESULTS: The rate of MIAC was 36.2% (21/58). Both amniotic fluid IL-6 and cervical C-reactive protein (CRP) showed to be independent predictors of MIAC. A cut-off level of cervical CRP≥1836 pg/mL showed a detection rate of 75%, false positive rate of 19% and positive and negative predictive values to predict MIAC of 67% and 87%, respectively. There were no independent biomarkers of MIAC either in the serum or vaginal compartment. CONCLUSION: A cervical inflammatory response mediated by CRP was observed in PPROM women with MIAC. Evaluation of serum or vaginal samples did not add valuable information regarding the outcome evaluated. Public Library of Science 2014-01-21 /pmc/articles/PMC3897420/ /pubmed/24465522 http://dx.doi.org/10.1371/journal.pone.0085277 Text en © 2014 Cobo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cobo, Teresa
Jacobsson, Bo
Kacerovsky, Marian
Hougaard, David M.
Skogstrand, Kristin
Gratacós, Eduard
Palacio, Montse
Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title_full Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title_fullStr Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title_full_unstemmed Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title_short Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes
title_sort systemic and local inflammatory response in women with preterm prelabor rupture of membranes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897420/
https://www.ncbi.nlm.nih.gov/pubmed/24465522
http://dx.doi.org/10.1371/journal.pone.0085277
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