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Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results

OBJECTIVE: To investigate microcirculatory differences between pathologic types of kidney tumor using 320-slice dynamic volume CT perfusion. METHODS: Perfusion imaging with 320-slice dynamic volume CT was prospectively performed in 85 patients with pathologically proven clear cell renal cell carcino...

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Autores principales: Chen, Chao, Liu, Qi, Hao, Qiang, Xu, Bing, Ma, Chao, Zhang, Huojun, Shen, Qianjin, Lu, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897451/
https://www.ncbi.nlm.nih.gov/pubmed/24465588
http://dx.doi.org/10.1371/journal.pone.0085522
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author Chen, Chao
Liu, Qi
Hao, Qiang
Xu, Bing
Ma, Chao
Zhang, Huojun
Shen, Qianjin
Lu, Jianping
author_facet Chen, Chao
Liu, Qi
Hao, Qiang
Xu, Bing
Ma, Chao
Zhang, Huojun
Shen, Qianjin
Lu, Jianping
author_sort Chen, Chao
collection PubMed
description OBJECTIVE: To investigate microcirculatory differences between pathologic types of kidney tumor using 320-slice dynamic volume CT perfusion. METHODS: Perfusion imaging with 320-slice dynamic volume CT was prospectively performed in 85 patients with pathologically proven clear cell renal cell carcinoma (RCC) (n = 66), papillary RCC (n = 7), chromophobe RCC (n = 5), angiomyolipoma (AML) with minimal fat (n = 7), or RCC (n = 78). Equivalent blood volume (Equiv BV), permeability surface-area product (PS; clearance/unit volume = permeability), and blood flow (BF) of tumor and normal renal cortex were measured and analyzed. Effective radiation dose was calculated. RESULTS: There was a significant difference in all three parameters between tumor and normal renal cortex (P<0.001). Equiv BV was significantly different between RCC and AML with minimal fat (P = 0.038) and between clear cell RCC and AML with minimal fat (P<0.001). Mean Equiv BV and BF were significantly higher in clear cell RCC than in papillary RCC (P<0.001 for both) and mean Equiv BV was higher in clear cell RCC than in chromophobe RCC (P<0.001). The effective radiation dose of the CT perfusion protocol was 18.5 mSv. CONCLUSION: Perfusion imaging using 320-slice dynamic volume CT can be used to evaluate hemodynamic features of the whole kidney and kidney tumors, which may be useful in the differential diagnosis of these four pathologic types of kidney tumor.
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spelling pubmed-38974512014-01-24 Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results Chen, Chao Liu, Qi Hao, Qiang Xu, Bing Ma, Chao Zhang, Huojun Shen, Qianjin Lu, Jianping PLoS One Research Article OBJECTIVE: To investigate microcirculatory differences between pathologic types of kidney tumor using 320-slice dynamic volume CT perfusion. METHODS: Perfusion imaging with 320-slice dynamic volume CT was prospectively performed in 85 patients with pathologically proven clear cell renal cell carcinoma (RCC) (n = 66), papillary RCC (n = 7), chromophobe RCC (n = 5), angiomyolipoma (AML) with minimal fat (n = 7), or RCC (n = 78). Equivalent blood volume (Equiv BV), permeability surface-area product (PS; clearance/unit volume = permeability), and blood flow (BF) of tumor and normal renal cortex were measured and analyzed. Effective radiation dose was calculated. RESULTS: There was a significant difference in all three parameters between tumor and normal renal cortex (P<0.001). Equiv BV was significantly different between RCC and AML with minimal fat (P = 0.038) and between clear cell RCC and AML with minimal fat (P<0.001). Mean Equiv BV and BF were significantly higher in clear cell RCC than in papillary RCC (P<0.001 for both) and mean Equiv BV was higher in clear cell RCC than in chromophobe RCC (P<0.001). The effective radiation dose of the CT perfusion protocol was 18.5 mSv. CONCLUSION: Perfusion imaging using 320-slice dynamic volume CT can be used to evaluate hemodynamic features of the whole kidney and kidney tumors, which may be useful in the differential diagnosis of these four pathologic types of kidney tumor. Public Library of Science 2014-01-21 /pmc/articles/PMC3897451/ /pubmed/24465588 http://dx.doi.org/10.1371/journal.pone.0085522 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chen, Chao
Liu, Qi
Hao, Qiang
Xu, Bing
Ma, Chao
Zhang, Huojun
Shen, Qianjin
Lu, Jianping
Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title_full Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title_fullStr Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title_full_unstemmed Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title_short Study of 320-Slice Dynamic Volume CT Perfusion in Different Pathologic Types of Kidney Tumor: Preliminary Results
title_sort study of 320-slice dynamic volume ct perfusion in different pathologic types of kidney tumor: preliminary results
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897451/
https://www.ncbi.nlm.nih.gov/pubmed/24465588
http://dx.doi.org/10.1371/journal.pone.0085522
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