The BDNF/TrkB Signaling Pathway Is Involved in Heat Hyperalgesia Mediated by Cdk5 in Rats

BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) has been shown to play an important role in mediating inflammation-induced heat hyperalgesia. However, the underlying mechanism remains unclear. The aim of this study was to determine whether roscovitine, an inhibitor of Cdk5, could reverse the heat hyper...

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Detalles Bibliográficos
Autores principales: Zhang, Hong-Hai, Zhang, Xiao-Qin, Xue, Qing-Sheng, Yan-Luo, Huang, Jin-Lu, Zhang, Su, Shao, Hai-Jun, Lu, Han, Wang, Wen-Yuan, Yu, Bu-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897472/
https://www.ncbi.nlm.nih.gov/pubmed/24465591
http://dx.doi.org/10.1371/journal.pone.0085536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897472/
https://www.ncbi.nlm.nih.gov/pubmed/24465591
http://dx.doi.org/10.1371/journal.pone.0085536

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