Cargando…

Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

SHARPIN is a key regulator of NFKB and integrin signaling. Mice lacking Sharpin develop a phenotype known as chronic proliferative dermatitis (CPDM), typified by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of seconda...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potter, Christopher S., Wang, Zhe, Silva, Kathleen A., Kennedy, Victoria E., Stearns, Timothy M., Burzenski, Lisa, Shultz, Leonard D., HogenEsch, Harm, Sundberg, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897490/ https://www.ncbi.nlm.nih.gov/pubmed/24465642 http://dx.doi.org/10.1371/journal.pone.0085666

Ejemplares similares

Loss of Function of the Mouse Sharpin Gene Results in Peyer’s Patch Regression
por: Seymour, Rosemarie, et al.
Publicado: (2013)

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice
por: Sundberg, John P., et al.
Publicado: (2020)

SHARPIN Is Essential for Cytokine Production, NF-κB Signaling, and Induction of Th1 Differentiation by Dendritic Cells
por: Wang, Zhe, et al.
Publicado: (2012)

SHARPIN is a key regulator of immune and inflammatory responses
por: Wang, Zhe, et al.
Publicado: (2012)

Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers
por: Franco, Jackeline, et al.
Publicado: (2018)

Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease
por: Franco, Jackeline, et al.
Publicado: (2020)

Enhanced development of functional human NK cells in NOD‐ scid‐IL2rg(null) mice expressing human IL15
por: Aryee, Ken‐Edwin, et al.
Publicado: (2022)

Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis
por: Franco, Jackeline, et al.
Publicado: (2021)

Mechanism of Immunopotentiation and Safety of Aluminum Adjuvants
por: HogenEsch, Harm
Publicado: (2013)

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice
por: Peuhu, Emilia, et al.
Publicado: (2017)

Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response
por: HogenEsch, Harm, et al.
Publicado: (2011)

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice
por: Brehm, Michael A., et al.
Publicado: (2010)

Selection of a suitable reference gene for quantitative gene expression in mouse lymph nodes after vaccination
por: Mosley, Yung-Yi C., et al.
Publicado: (2017)

Intestinal colonization with Candida auris and mucosal immune response in mice treated with cefoperazone oral antibiotic
por: Das, Diprasom, et al.
Publicado: (2023)

Distinct role of IL-1β in instigating disease in Sharpin(cpdm) mice
por: Gurung, Prajwal, et al.
Publicado: (2016)

Aluminum Adjuvants—‘Back to the Future’
por: Laera, Donatello, et al.
Publicado: (2023)

Chronic Proliferative Dermatitis in Mice: NFκB Activation Autoinflammatory Disease
por: Liang, Yanhua
Publicado: (2011)

IL-1 inhibition in autoinflammatory diseases
por: Martini, Alberto
Publicado: (2012)

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want
por: HogenEsch, Harm, et al.
Publicado: (2018)

Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice
por: Mosley, Yung-Yi C., et al.
Publicado: (2019)

Alpha-D-glucan-based vaccine adjuvants: Current status and future perspectives
por: Patil, Veerupaxagouda, et al.
Publicado: (2022)

Mechanism of activation of porcine dendritic cells by an α-D-glucan nanoparticle adjuvant and a nanoparticle/poly(I:C) combination adjuvant
por: Hernandez-Franco, Juan F., et al.
Publicado: (2022)

Management of Monogenic IL-1 Mediated Autoinflammatory Diseases in Childhood
por: Welzel, Tatjana, et al.
Publicado: (2021)

IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
por: Broderick, Lori, et al.
Publicado: (2022)

Advances in the Structural and Physiological Functions of SHARPIN
por: Yu, Beiming, et al.
Publicado: (2022)

Role of IL-1b in NLRP12-associated autoinflammatory disorders and resistance to anti-IL-1 therapy
por: Jeru, Isabelle, et al.
Publicado: (2011)

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
por: Kim, Man Lyang, et al.
Publicado: (2015)

Increased expression of Cxcr3 and its ligands, Cxcl9, and Cxcl10, during the development of alopecia areata in the mouse
por: McPhee, Caroline G., et al.
Publicado: (2012)

Porcine Circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice
por: Kiupel, Matti, et al.
Publicado: (2005)

Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida albicans in the Intestine
por: Datta, Abhishek, et al.
Publicado: (2022)

NOD-scidIl2rg(tm1Wjl) and NOD-Rag1(null)Il2rg(tm1Wjl): A Model for Stromal Cell–Tumor Cell Interaction for Human Colon Cancer
por: Maykel, Justin, et al.
Publicado: (2014)

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?
por: Carta, Sonia, et al.
Publicado: (2017)

Dengue Virus Infection and Virus-Specific HLA-A2 Restricted Immune Responses in Humanized NOD-scid IL2rγ(null) Mice
por: Jaiswal, Smita, et al.
Publicado: (2009)

3162 Colonization of Pregnant Women with Group B streptococcus in Latin America and Infant Outcomes
por: HogenEsch, Elena, et al.
Publicado: (2019)

Schnitzler syndrome, a rare autoinflammatory disease. Complete response to IL-1 blockade
por: Faggioli, Paola, et al.
Publicado: (2017)

8. An autoinflammatory syndrome resembling Castleman’s disease with excellent response to IL-6 blockade
por: Chakravorty, Mithun, et al.
Publicado: (2019)

NLRP12 and IL36RN mutations in a Portuguese woman with autoinflammatory syndrome
por: Antunes-Duarte, Sofia, et al.
Publicado: (2022)

Improved B cell development in humanized NOD‐scid IL2Rγ(null) mice transgenically expressing human stem cell factor, granulocyte‐macrophage colony‐stimulating factor and interleukin‐3
por: Jangalwe, Sonal, et al.
Publicado: (2016)

Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin
por: Jurczyk, Agata, et al.
Publicado: (2013)

The Central Role of Anti-IL-1 Blockade in the Treatment of Monogenic and Multi-Factorial Autoinflammatory Diseases
por: Federici, Silvia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mlv45bom0m1jtcosirb0glc5d3