Cargando…

Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

15-lipoxygenase-1 (15-LOX-1) plays an important role in angiogenesis, but how it works still remains a controversial subject. The aims of our study are focused on determining whether or not 15-LOX-1 inhibiting oxygen-induced ischemic retinal neovascularization (RNV) and the underlying regulatory mec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhi, He, Tao, Du, Ke, Xing, Yi-Qiao, Run, Yuan-Min, Yan, Ying, Shen, Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897531/ https://www.ncbi.nlm.nih.gov/pubmed/24465728 http://dx.doi.org/10.1371/journal.pone.0085824

Ejemplares similares

Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression
por: Li, Zhi, et al.
Publicado: (2012)

Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization
por: Al-Shabrawey, Mohamed, et al.
Publicado: (2011)

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells
por: von Knethen, A, et al.
Publicado: (2012)

Regulation and Functions of 15-Lipoxygenases in Human Macrophages
por: Snodgrass, Ryan G., et al.
Publicado: (2019)

Deguelin inhibits retinal neovascularization by down-regulation of HIF-1α in oxygen-induced retinopathy
por: Kim, J H, et al.
Publicado: (2008)

PPARγ Agonists: Potential as Therapeutics for Neovascular Retinopathies
por: Pershadsingh, Harrihar A., et al.
Publicado: (2008)

Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
por: Kim, Jeong Hun, et al.
Publicado: (2009)

Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. Diabetes 2011;60:614–624
por: Al-Shabrawey, M, et al.
Publicado: (2013)

A novel role for 12/15-lipoxygenase in regulating autophagy
por: Morgan, Alwena H., et al.
Publicado: (2014)

ALK7 Acts as a Positive Regulator of Macrophage Activation through Down-Regulation of PPARγ Expression
por: Cheng, Wen-Lin, et al.
Publicado: (2021)

Influenza virus causes lung immunopathology through down-regulating PPARγ activity in macrophages
por: Zhang, Hongbo, et al.
Publicado: (2022)

PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis
por: Ye, Sihao, et al.
Publicado: (2020)

Redox Regulation of PPARγ in Polarized Macrophages
por: Trümper, Verena, et al.
Publicado: (2020)

Ups and downs: The PPARγ/p-PPARγ seesaw of follistatin-like 1 and integrin receptor signaling in adipogenesis
por: Fang, Dongliang, et al.
Publicado: (2021)

Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
por: Benatzy, Yvonne, et al.
Publicado: (2022)

Laquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK
por: Wang, Guang, et al.
Publicado: (2020)

Activation of β(2)-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ
por: Zhou, Jing, et al.
Publicado: (2020)

Overexpression and Down-Regulation of Barley Lipoxygenase LOX2.2 Affects Jasmonate-Regulated Genes and Aphid Fecundity
por: Losvik, Aleksandra, et al.
Publicado: (2017)

CXCR4 in Cancer and Its Regulation by PPARγ
por: Richard, Cynthia Lee, et al.
Publicado: (2008)

Structural Basis for the Regulation of PPARγ Activity by Imatinib
por: Jang, Jun Young, et al.
Publicado: (2019)

PPARγ Regulates Triclosan Induced Placental Dysfunction
por: Li, Jing, et al.
Publicado: (2021)

Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K/Akt pathway
por: Zhuang, Zhi, et al.
Publicado: (2015)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Poster 113: Epigenetic Regulation of PPARγ Rescues Articular Chondrocytes from Catabolic State Suggesting PPARγ as a Potential Target to Slow Down Progression of OA in Hip FAI
por: Kamenaga, Tomoyuki, et al.
Publicado: (2023)

12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation
por: Lindley, Alexa R., et al.
Publicado: (2010)

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase
por: Hinman, Andrew, et al.
Publicado: (2018)

Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas
por: Barooni, Alaleh Bayat, et al.
Publicado: (2019)

12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice
por: Miyata, Jun, et al.
Publicado: (2021)

Effects of Inflammatory Factor Expression Regulated by 12/15 Lipoxygenase on Obesity-Related Nephropathy
por: Liu, Nian, et al.
Publicado: (2022)

Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin
por: Woo, Seon Min, et al.
Publicado: (2017)

STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina
por: Gutsaeva, Diana R., et al.
Publicado: (2017)

SUMOylation of PPARγ by Rosiglitazone Prevents LPS-Induced NCoR Degradation Mediating Down Regulation of Chemokines Expression in Renal Proximal Tubular Cells
por: Lu, Ying, et al.
Publicado: (2013)

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
por: Czapski, Grzegorz A., et al.
Publicado: (2015)

Regulation of Tissue Inflammation by 12-Lipoxygenases
por: Kulkarni, Abhishek, et al.
Publicado: (2021)

A role for CNS PPARγ in the regulation of energy balance
por: Ryan, Karen K., et al.
Publicado: (2011)

The regulation of catalase activity by PPAR γ is affected by α-synuclein
por: Yakunin, Eugenia, et al.
Publicado: (2014)

Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis
por: Lee, Ji-Eun, et al.
Publicado: (2014)

Isoform-specific functions of PPARγ in gene regulation and metabolism
por: Hu, Wenxiang, et al.
Publicado: (2022)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_fe1fokm3ndj3e11khj4tko0on0