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Toll-Like Receptor 4 Stimulation before or after Streptococcus pneumoniae Induced Sepsis Improves Survival and Is Dependent on T-Cells

INTRODUCTION: Endotoxin tolerance improves outcomes from gram negative sepsis but the underlying mechanism is not known. We determined if endotoxin tolerance before or after pneumococcal sepsis improved survival and the role of lymphocytes in this protection. METHODS: Mice received lipopolysaccharid...

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Detalles Bibliográficos
Autores principales:	Musie, Edgar, Moore, Christopher C., Martin, Edward N., Scheld, W. Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897608/ https://www.ncbi.nlm.nih.gov/pubmed/24465843 http://dx.doi.org/10.1371/journal.pone.0086015

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