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p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line

KRAS is mutated in ∼40% of colorectal cancer (CRC), and there are limited effective treatments for advanced KRAS mutant CRC. Therefore, it is crucial that downstream mediators of oncogenic KRAS continue to be studied. We identified p190RhoGAP as being phosphorylated in the DLD1 CRC cell line, which...

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Detalles Bibliográficos
Autores principales:	Organ, Shawna L., Hai, Josephine, Radulovich, Nikolina, Marshall, Christopher B., Leung, Lisa, Sasazuki, Takehiko, Shirasawa, Senji, Zhu, Chang-Qi, Navab, Roya, Ikura, Mitsuhiko, Tsao, Ming-Sound
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897622/ https://www.ncbi.nlm.nih.gov/pubmed/24465899 http://dx.doi.org/10.1371/journal.pone.0086103

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