Release of Tensile Strain on Engineered Human Tendon Tissue Disturbs Cell Adhesions, Changes Matrix Architecture, and Induces an Inflammatory Phenotype

Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated the response to tension release, with regard to matrix proteins, pro-inflamm...

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Detalles Bibliográficos
Autores principales: Bayer, Monika L., Schjerling, Peter, Herchenhan, Andreas, Zeltz, Cedric, Heinemeier, Katja M., Christensen, Lise, Krogsgaard, Michael, Gullberg, Donald, Kjaer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897642/
https://www.ncbi.nlm.nih.gov/pubmed/24465881
http://dx.doi.org/10.1371/journal.pone.0086078

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