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Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia

RATIONALE AND OBJECTIVE: Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/−) mice were developed to investigate the effect of arginase-1 related arg...

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Detalles Bibliográficos
Autores principales:	Wijnands, Karolina A. P., Hoeksema, Marten A., Meesters, Dennis M., van den Akker, Nynke M. S., Molin, Daniel G. M., Briedé, Jacob J., Ghosh, Mitrajit, Köhler, S. Eleonore, van Zandvoort, Marc A. M. J., de Winther, Menno P. J., Buurman, Wim A., Lamers, Wouter H., Poeze, Martijn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897658/ https://www.ncbi.nlm.nih.gov/pubmed/24465919 http://dx.doi.org/10.1371/journal.pone.0086135

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