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Transcranial Direct Current Stimulation in Schizophrenia

Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS. This review summarizes the research work that has examined the effec...

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Autores principales: Agarwal, Sri Mahavir, Shivakumar, Venkataram, Bose, Anushree, Subramaniam, Aditi, Nawani, Hema, Chhabra, Harleen, Kalmady, Sunil V., Narayanaswamy, Janardhanan C., Venkatasubramanian, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897759/
https://www.ncbi.nlm.nih.gov/pubmed/24465247
http://dx.doi.org/10.9758/cpn.2013.11.3.118
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author Agarwal, Sri Mahavir
Shivakumar, Venkataram
Bose, Anushree
Subramaniam, Aditi
Nawani, Hema
Chhabra, Harleen
Kalmady, Sunil V.
Narayanaswamy, Janardhanan C.
Venkatasubramanian, Ganesan
author_facet Agarwal, Sri Mahavir
Shivakumar, Venkataram
Bose, Anushree
Subramaniam, Aditi
Nawani, Hema
Chhabra, Harleen
Kalmady, Sunil V.
Narayanaswamy, Janardhanan C.
Venkatasubramanian, Ganesan
author_sort Agarwal, Sri Mahavir
collection PubMed
description Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS. This review summarizes the research work that has examined the effects of tDCS in schizophrenia patients with respect to symptom amelioration, cognitive enhancement and neuroplasticity evaluation. tDCS is emerging as a safe, rapid and effective treatment for various aspects of schizophrenia symptoms ranging from auditory hallucinations-for which the effect is most marked, to negative symptoms and cognitive symptoms as well. An interesting line of investigation involves using tDCS for altering and examining neuroplasticity in patients and healthy subjects and is likely to lead to new insights into the neurological aberrations and pathophysiology of schizophrenia. The mechanistic aspects of the technique are discussed in brief. Future work should focus on establishing the clinical efficacy of this novel technique and on evaluating this modality as an adjunct to cognitive enhancement protocols. Understanding the mechanism of action of tDCS as well as the determinants and neurobiological correlates of clinical response to tDCS remains an important goal, which will help us expand the clinical applications of tDCS for the treatment of patients with schizophrenia.
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spelling pubmed-38977592014-01-24 Transcranial Direct Current Stimulation in Schizophrenia Agarwal, Sri Mahavir Shivakumar, Venkataram Bose, Anushree Subramaniam, Aditi Nawani, Hema Chhabra, Harleen Kalmady, Sunil V. Narayanaswamy, Janardhanan C. Venkatasubramanian, Ganesan Clin Psychopharmacol Neurosci Review Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS. This review summarizes the research work that has examined the effects of tDCS in schizophrenia patients with respect to symptom amelioration, cognitive enhancement and neuroplasticity evaluation. tDCS is emerging as a safe, rapid and effective treatment for various aspects of schizophrenia symptoms ranging from auditory hallucinations-for which the effect is most marked, to negative symptoms and cognitive symptoms as well. An interesting line of investigation involves using tDCS for altering and examining neuroplasticity in patients and healthy subjects and is likely to lead to new insights into the neurological aberrations and pathophysiology of schizophrenia. The mechanistic aspects of the technique are discussed in brief. Future work should focus on establishing the clinical efficacy of this novel technique and on evaluating this modality as an adjunct to cognitive enhancement protocols. Understanding the mechanism of action of tDCS as well as the determinants and neurobiological correlates of clinical response to tDCS remains an important goal, which will help us expand the clinical applications of tDCS for the treatment of patients with schizophrenia. Korean College of Neuropsychopharmacology 2013-12 2013-12-24 /pmc/articles/PMC3897759/ /pubmed/24465247 http://dx.doi.org/10.9758/cpn.2013.11.3.118 Text en Copyright© 2013, Korean College of Neuropsychopharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Agarwal, Sri Mahavir
Shivakumar, Venkataram
Bose, Anushree
Subramaniam, Aditi
Nawani, Hema
Chhabra, Harleen
Kalmady, Sunil V.
Narayanaswamy, Janardhanan C.
Venkatasubramanian, Ganesan
Transcranial Direct Current Stimulation in Schizophrenia
title Transcranial Direct Current Stimulation in Schizophrenia
title_full Transcranial Direct Current Stimulation in Schizophrenia
title_fullStr Transcranial Direct Current Stimulation in Schizophrenia
title_full_unstemmed Transcranial Direct Current Stimulation in Schizophrenia
title_short Transcranial Direct Current Stimulation in Schizophrenia
title_sort transcranial direct current stimulation in schizophrenia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897759/
https://www.ncbi.nlm.nih.gov/pubmed/24465247
http://dx.doi.org/10.9758/cpn.2013.11.3.118
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