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Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patient...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean College of Neuropsychopharmacology
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897766/ https://www.ncbi.nlm.nih.gov/pubmed/24465254 http://dx.doi.org/10.9758/cpn.2013.11.3.165 |
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author | Min, Aran Kim, Daeho |
author_facet | Min, Aran Kim, Daeho |
author_sort | Min, Aran |
collection | PubMed |
description | We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic. |
format | Online Article Text |
id | pubmed-3897766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean College of Neuropsychopharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38977662014-01-24 Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases Min, Aran Kim, Daeho Clin Psychopharmacol Neurosci Case Report We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic. Korean College of Neuropsychopharmacology 2013-12 2013-12-24 /pmc/articles/PMC3897766/ /pubmed/24465254 http://dx.doi.org/10.9758/cpn.2013.11.3.165 Text en Copyright© 2013, Korean College of Neuropsychopharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Min, Aran Kim, Daeho Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title | Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title_full | Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title_fullStr | Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title_full_unstemmed | Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title_short | Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases |
title_sort | blonanserin-induced mood alteration in schizophrenia and schizoaffective disorder: two cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897766/ https://www.ncbi.nlm.nih.gov/pubmed/24465254 http://dx.doi.org/10.9758/cpn.2013.11.3.165 |
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