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Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases

We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patient...

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Autores principales: Min, Aran, Kim, Daeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897766/
https://www.ncbi.nlm.nih.gov/pubmed/24465254
http://dx.doi.org/10.9758/cpn.2013.11.3.165
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author Min, Aran
Kim, Daeho
author_facet Min, Aran
Kim, Daeho
author_sort Min, Aran
collection PubMed
description We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic.
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spelling pubmed-38977662014-01-24 Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases Min, Aran Kim, Daeho Clin Psychopharmacol Neurosci Case Report We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic. Korean College of Neuropsychopharmacology 2013-12 2013-12-24 /pmc/articles/PMC3897766/ /pubmed/24465254 http://dx.doi.org/10.9758/cpn.2013.11.3.165 Text en Copyright© 2013, Korean College of Neuropsychopharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Min, Aran
Kim, Daeho
Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title_full Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title_fullStr Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title_full_unstemmed Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title_short Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
title_sort blonanserin-induced mood alteration in schizophrenia and schizoaffective disorder: two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897766/
https://www.ncbi.nlm.nih.gov/pubmed/24465254
http://dx.doi.org/10.9758/cpn.2013.11.3.165
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