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Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling

Proteolytic processing of the amyloid precursor protein (APP) by the β- and γ-secretases releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the etiology of Alzheimer's disease (AD). The α-secretase cleaves APP in the Aβ peptide sequence to generate soluble...

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Detalles Bibliográficos
Autores principales:	Pimenova, Anna A., Thathiah, Amantha, De Strooper, Bart, Tesseur, Ina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897773/ https://www.ncbi.nlm.nih.gov/pubmed/24466315 http://dx.doi.org/10.1371/journal.pone.0087014

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