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Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fu...

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Detalles Bibliográficos
Autores principales:	Thangapazham, Rajesh, Saenz, Francisco, Katta, Shilpa, Mohamed, Ahmed A, Tan, Shyh-Han, Petrovics, Gyorgy, Srivastava, Shiv, Dobi, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897978/ https://www.ncbi.nlm.nih.gov/pubmed/24418414 http://dx.doi.org/10.1186/1471-2407-14-16

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