Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity()

The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxic...

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Detalles Bibliográficos
Autores principales: Kruppa, Antonina J., Ott, Stanislav, Chandraratna, Dhia S., Irving, James A., Page, Richard M., Speretta, Elena, Seto, Tiffany, Camargo, Luiz Miguel, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898073/
https://www.ncbi.nlm.nih.gov/pubmed/23911349
http://dx.doi.org/10.1016/j.bbadis.2013.07.019

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