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Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East()
Foot-and-mouth disease viruses (FMDV) from serotype A exhibit high antigenic diversity. Within the Middle East, a strain called A-Iran-05 emerged in 2003, and subsequently replaced the A-Iran-96 and A-Iran-99 strains that were previously circulating in the region. Viruses from this strain did not se...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898079/ https://www.ncbi.nlm.nih.gov/pubmed/24035435 http://dx.doi.org/10.1016/j.vaccine.2013.08.102 |
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author | Upadhyaya, Sasmita Ayelet, Gelagay Paul, Guntram King, Donald P. Paton, David J. Mahapatra, Mana |
author_facet | Upadhyaya, Sasmita Ayelet, Gelagay Paul, Guntram King, Donald P. Paton, David J. Mahapatra, Mana |
author_sort | Upadhyaya, Sasmita |
collection | PubMed |
description | Foot-and-mouth disease viruses (FMDV) from serotype A exhibit high antigenic diversity. Within the Middle East, a strain called A-Iran-05 emerged in 2003, and subsequently replaced the A-Iran-96 and A-Iran-99 strains that were previously circulating in the region. Viruses from this strain did not serologically match with the established A/Iran/96 vaccine, although most early samples matched with the older A22/Iraq vaccine. However, many viruses from this strain collected after 2006 had poor serological match with the A22/Iraq vaccine necessitating the development of a new vaccine strain (A/TUR/2006). More recently, viruses from the region now exhibit lower cross-reactivity with the A/TUR/2006 antisera highlighting the inadequacy of the serotype A vaccines used in the region. In order to understand the genetic basis of these antigenic phenotypes, we have determined the full capsid sequence for 57 Middle Eastern viruses isolated between 1996 and 2011 and analysed these data in context of antigenic relationship (r(1)) values that were generated using antisera to A22/Iraq and A/TUR/2006. Comparisons of capsid sequences identified substitutions in neutralising antigenic sites (1, 2 and 4), which either individually or together underpin these observed antigenic phenotypes. |
format | Online Article Text |
id | pubmed-3898079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38980792014-01-24 Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() Upadhyaya, Sasmita Ayelet, Gelagay Paul, Guntram King, Donald P. Paton, David J. Mahapatra, Mana Vaccine Article Foot-and-mouth disease viruses (FMDV) from serotype A exhibit high antigenic diversity. Within the Middle East, a strain called A-Iran-05 emerged in 2003, and subsequently replaced the A-Iran-96 and A-Iran-99 strains that were previously circulating in the region. Viruses from this strain did not serologically match with the established A/Iran/96 vaccine, although most early samples matched with the older A22/Iraq vaccine. However, many viruses from this strain collected after 2006 had poor serological match with the A22/Iraq vaccine necessitating the development of a new vaccine strain (A/TUR/2006). More recently, viruses from the region now exhibit lower cross-reactivity with the A/TUR/2006 antisera highlighting the inadequacy of the serotype A vaccines used in the region. In order to understand the genetic basis of these antigenic phenotypes, we have determined the full capsid sequence for 57 Middle Eastern viruses isolated between 1996 and 2011 and analysed these data in context of antigenic relationship (r(1)) values that were generated using antisera to A22/Iraq and A/TUR/2006. Comparisons of capsid sequences identified substitutions in neutralising antigenic sites (1, 2 and 4), which either individually or together underpin these observed antigenic phenotypes. Elsevier Science 2014-01-23 /pmc/articles/PMC3898079/ /pubmed/24035435 http://dx.doi.org/10.1016/j.vaccine.2013.08.102 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Upadhyaya, Sasmita Ayelet, Gelagay Paul, Guntram King, Donald P. Paton, David J. Mahapatra, Mana Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title | Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title_full | Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title_fullStr | Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title_full_unstemmed | Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title_short | Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East() |
title_sort | genetic basis of antigenic variation in foot-and-mouth disease serotype a viruses from the middle east() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898079/ https://www.ncbi.nlm.nih.gov/pubmed/24035435 http://dx.doi.org/10.1016/j.vaccine.2013.08.102 |
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