Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction

The IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB), prevents IFITM3-mediated restriction of IAV, thereby increasing viral replication. Consistent with its neutralization of IFITM3, a clinical preparati...

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Detalles Bibliográficos
Autores principales: Lin, Tsai-Yu, Chin, Christopher R., Everitt, Aaron R., Clare, Simon, Perreira, Jill M., Savidis, George, Aker, Aaron M., John, Sinu P., Sarlah, David, Carreira, Erick M., Elledge, Stephen J., Kellam, Paul, Brass, Abraham L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898084/
https://www.ncbi.nlm.nih.gov/pubmed/24268777
http://dx.doi.org/10.1016/j.celrep.2013.10.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898084/
https://www.ncbi.nlm.nih.gov/pubmed/24268777
http://dx.doi.org/10.1016/j.celrep.2013.10.033

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