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Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)

BACKGROUND: Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers and is known to inhibit Ras/Raf/MEK/ERK signaling. By suppressing the activation of the NFkB/SNAIL circuit, RKIP can regulate the induction of epithelial-mesenchymal tra...

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Detalles Bibliográficos
Autores principales:	Karamitopoulou, Eva, Zlobec, Inti, Gloor, Beat, Kondi-Pafiti, Agathi, Lugli, Alessandro, Perren, Aurel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898115/ https://www.ncbi.nlm.nih.gov/pubmed/24330423 http://dx.doi.org/10.1186/1479-5876-11-311

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