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Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes

Primary cilia can act as either a negative or positive regulator of the hedgehog (Hh) signaling pathway. Many cartilage tumors are characterized by abnormal activation of the Hh pathway. Here, we report that the presence of primary cilia occurs at a low frequency (12.4%) in neoplastic chondrocytes f...

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Detalles Bibliográficos
Autores principales:	Ho, L, Ali, S A, Al-Jazrawe, M, Kandel, R, Wunder, J S, Alman, B A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898120/ https://www.ncbi.nlm.nih.gov/pubmed/23246966 http://dx.doi.org/10.1038/onc.2012.588

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