Dynactin Deficiency in the CNS of Humans with Sporadic ALS and Mice with Genetically Determined Motor Neuron Degeneration

Dynactin is a complex motor protein involved in the retrograde axonal transport disturbances of which may lead to amyotrophic lateral sclerosis (ALS). Mice with hSOD1G93A mutation develop ALS-like symptoms and are used as a model for the disease studies. Similar symptoms demonstrate Cra1 mice, with...

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Detalles Bibliográficos
Autores principales: Kuźma-Kozakiewicz, Magdalena, Chudy, Agnieszka, Kaźmierczak, Beata, Dziewulska, Dorota, Usarek, Ewa, Barańczyk-Kuźma, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898179/
https://www.ncbi.nlm.nih.gov/pubmed/24078265
http://dx.doi.org/10.1007/s11064-013-1160-7

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