Genomic instability in pre-neoplastic colonic lesions

Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common...

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Detalles Bibliográficos
Autores principales: Shaw, J A, Graham, T A, Stebbing, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898279/
https://www.ncbi.nlm.nih.gov/pubmed/23396367
http://dx.doi.org/10.1038/onc.2013.21
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author Shaw, J A
Graham, T A
Stebbing, J
author_facet Shaw, J A
Graham, T A
Stebbing, J
author_sort Shaw, J A
collection PubMed
description Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual glands of pre-malignant colorectal lesions and raises interesting questions about the role of MSI in the development of colorectal carcinoma.
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spelling pubmed-38982792014-01-24 Genomic instability in pre-neoplastic colonic lesions Shaw, J A Graham, T A Stebbing, J Oncogene Commentary Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual glands of pre-malignant colorectal lesions and raises interesting questions about the role of MSI in the development of colorectal carcinoma. Nature Publishing Group 2013-11-14 2013-02-11 /pmc/articles/PMC3898279/ /pubmed/23396367 http://dx.doi.org/10.1038/onc.2013.21 Text en Copyright © 2013 Macmillan Publishers Limited
spellingShingle Commentary
Shaw, J A
Graham, T A
Stebbing, J
Genomic instability in pre-neoplastic colonic lesions
title Genomic instability in pre-neoplastic colonic lesions
title_full Genomic instability in pre-neoplastic colonic lesions
title_fullStr Genomic instability in pre-neoplastic colonic lesions
title_full_unstemmed Genomic instability in pre-neoplastic colonic lesions
title_short Genomic instability in pre-neoplastic colonic lesions
title_sort genomic instability in pre-neoplastic colonic lesions
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898279/
https://www.ncbi.nlm.nih.gov/pubmed/23396367
http://dx.doi.org/10.1038/onc.2013.21
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