DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes

Promoter CpG island hypermethylation of tumor suppressor genes is an epigenetic hallmark of human cancer commonly associated with nucleosome occupancy and the transcriptional silencing of the neighboring gene. Nucleosomes can determine the underlying DNA methylation status. Herein, we show that the...

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Detalles Bibliográficos
Autores principales: Portela, A, Liz, J, Nogales, V, Setién, F, Villanueva, A, Esteller, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898323/
https://www.ncbi.nlm.nih.gov/pubmed/23686312
http://dx.doi.org/10.1038/onc.2013.162

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