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Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P(3) and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

JP2 (junctophilin-2) is believed to hold the transverse tubular and jSR (junctional sarcoplasmic reticulum) membranes in a precise geometry that facilitates excitation–contraction coupling in cardiomyocytes. We have expressed and purified human JP2 and shown using electron microscopy that the protei...

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Detalles Bibliográficos
Autores principales:	Bennett, Hayley J., Davenport, John Bernard, Collins, Richard F., Trafford, Andrew W., Pinali, Christian, Kitmitto, Ashraf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898329/ https://www.ncbi.nlm.nih.gov/pubmed/24001019 http://dx.doi.org/10.1042/BJ20130591

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