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Plant Polyisoprenoids and Control of Cholesterol Level

The ability of plant polyisoprenoids (polyprenols and polyprenyl phosphates) to diminish the levels of serum cholesterol affecting its biosynthetic pathway are highlighted here. Possible mechanism of such process is discussed. It is also noted that polyisoprenoids can prevent toxic injuries of the l...

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Autores principales: Pronin, Alexander V., Danilov, Leonid L., Narovlyansky, Alexander N., Sanin, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898360/
https://www.ncbi.nlm.nih.gov/pubmed/23995915
http://dx.doi.org/10.1007/s00005-013-0253-y
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author Pronin, Alexander V.
Danilov, Leonid L.
Narovlyansky, Alexander N.
Sanin, Alexander V.
author_facet Pronin, Alexander V.
Danilov, Leonid L.
Narovlyansky, Alexander N.
Sanin, Alexander V.
author_sort Pronin, Alexander V.
collection PubMed
description The ability of plant polyisoprenoids (polyprenols and polyprenyl phosphates) to diminish the levels of serum cholesterol affecting its biosynthetic pathway are highlighted here. Possible mechanism of such process is discussed. It is also noted that polyisoprenoids can prevent toxic injuries of the liver and restore disturbed hepatic functions. The possibility of polyprenyl phosphates to reveal at the same time anti-inflammatory action suppressing lipoxygenase activity and lowering the levels of proinflammatory cytokines will be illustrated. Attention will be focused on the potential usefulness of plant polyisoprenoids in the course of prevention and treatment of hypercholesterolemia. High efficiency for combined use of polyprenyl phosphate and β-sitosterol, which leads to substantial enhancement of the ability to overcome hypercholesterolemia versus the individual constituents will be demonstrated.
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spelling pubmed-38983602014-01-28 Plant Polyisoprenoids and Control of Cholesterol Level Pronin, Alexander V. Danilov, Leonid L. Narovlyansky, Alexander N. Sanin, Alexander V. Arch Immunol Ther Exp (Warsz) Review The ability of plant polyisoprenoids (polyprenols and polyprenyl phosphates) to diminish the levels of serum cholesterol affecting its biosynthetic pathway are highlighted here. Possible mechanism of such process is discussed. It is also noted that polyisoprenoids can prevent toxic injuries of the liver and restore disturbed hepatic functions. The possibility of polyprenyl phosphates to reveal at the same time anti-inflammatory action suppressing lipoxygenase activity and lowering the levels of proinflammatory cytokines will be illustrated. Attention will be focused on the potential usefulness of plant polyisoprenoids in the course of prevention and treatment of hypercholesterolemia. High efficiency for combined use of polyprenyl phosphate and β-sitosterol, which leads to substantial enhancement of the ability to overcome hypercholesterolemia versus the individual constituents will be demonstrated. Springer Basel 2013-08-31 2014 /pmc/articles/PMC3898360/ /pubmed/23995915 http://dx.doi.org/10.1007/s00005-013-0253-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Pronin, Alexander V.
Danilov, Leonid L.
Narovlyansky, Alexander N.
Sanin, Alexander V.
Plant Polyisoprenoids and Control of Cholesterol Level
title Plant Polyisoprenoids and Control of Cholesterol Level
title_full Plant Polyisoprenoids and Control of Cholesterol Level
title_fullStr Plant Polyisoprenoids and Control of Cholesterol Level
title_full_unstemmed Plant Polyisoprenoids and Control of Cholesterol Level
title_short Plant Polyisoprenoids and Control of Cholesterol Level
title_sort plant polyisoprenoids and control of cholesterol level
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898360/
https://www.ncbi.nlm.nih.gov/pubmed/23995915
http://dx.doi.org/10.1007/s00005-013-0253-y
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