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Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke

BACKGROUND: Benzene is an established human leukemogen, with a ubiquitous environmental presence leading to significant population exposure. In a genome-wide functional screen in the yeast Saccharomyces cerevisiae, inactivation of IRA2, a yeast ortholog of the human tumor suppressor gene NF1 (Neurof...

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Detalles Bibliográficos
Autores principales:	North, Matthew, Shuga, Joe, Fromowitz, Michele, Loguinov, Alexandre, Shannon, Kevin, Zhang, Luoping, Smith, Martyn T, Vulpe, Chris D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898384/ https://www.ncbi.nlm.nih.gov/pubmed/24386979 http://dx.doi.org/10.1186/1471-2407-14-6

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