Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

BACKGROUND: Familial British and Familial Danish dementias (FBD and FDD, respectively) are associated with mutations in the BRI(2) gene. Processing of the mutated BRI(2) protein leads to the accumulation in the brain of the 34-mer amyloid Bri (ABri) and amyloid Dan (ADan) peptides, accompanied by ne...

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Detalles Bibliográficos
Autores principales: Marcora, María S, Fernández-Gamba, Agata C, Avendaño, Luz A, Rotondaro, Cecilia, Podhajcer, Osvaldo L, Vidal, Rubén, Morelli, Laura, Ceriani, María F, Castaño, Eduardo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898387/
https://www.ncbi.nlm.nih.gov/pubmed/24405716
http://dx.doi.org/10.1186/1750-1326-9-5

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