Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474)

Proteasome inhibitors have been proven to be effective anticancer compounds in many tumor models, including glioblastoma multiforme (GBM). In this study, we found that the proteasome inhibitor Velcade (PS-341/bortezomib) caused GBM cell death while simultaneously activating the PI3K/Akt pathway. The...

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Detalles Bibliográficos
Autores principales: LIN, LEHANG, GAUT, DARIA, HU, KAISHUN, YAN, HAIYAN, YIN, DONG, KOEFFLER, H. PHILLIP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898871/
https://www.ncbi.nlm.nih.gov/pubmed/24297065
http://dx.doi.org/10.3892/ijo.2013.2205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898871/
https://www.ncbi.nlm.nih.gov/pubmed/24297065
http://dx.doi.org/10.3892/ijo.2013.2205

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