P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain

BACKGROUND: Mitochondrial dysfunction contributes to degenerative neurological disorders, consequently there is a need for mitochondria-targeted therapies that are effective within the brain. One approach to deliver pharmacophores is by conjugation to the lipophilic triphenylphosphonium (TPP) cation...

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Detalles Bibliográficos
Autores principales: Porteous, Carolyn M., Menon, David K., Aigbirhio, Franklin I., Smith, Robin A.J., Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898886/
https://www.ncbi.nlm.nih.gov/pubmed/23454352
http://dx.doi.org/10.1016/j.bbagen.2013.02.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898886/
https://www.ncbi.nlm.nih.gov/pubmed/23454352
http://dx.doi.org/10.1016/j.bbagen.2013.02.005

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