Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()

Hyperpolarized (83)Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the (83)Kr hyperpolarization and the resulting signal intensity. Using t...

Descripción completa

Detalles Bibliográficos
Autores principales: Six, Joseph S., Hughes-Riley, Theodore, Lilburn, David M.L., Dorkes, Alan C., Stupic, Karl F., Shaw, Dominick E., Morris, Peter G., Hall, Ian P., Pavlovskaya, Galina E., Meersmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898897/
https://www.ncbi.nlm.nih.gov/pubmed/24144493
http://dx.doi.org/10.1016/j.mri.2013.08.007
_version_ 1782300485277974528
author Six, Joseph S.
Hughes-Riley, Theodore
Lilburn, David M.L.
Dorkes, Alan C.
Stupic, Karl F.
Shaw, Dominick E.
Morris, Peter G.
Hall, Ian P.
Pavlovskaya, Galina E.
Meersmann, Thomas
author_facet Six, Joseph S.
Hughes-Riley, Theodore
Lilburn, David M.L.
Dorkes, Alan C.
Stupic, Karl F.
Shaw, Dominick E.
Morris, Peter G.
Hall, Ian P.
Pavlovskaya, Galina E.
Meersmann, Thomas
author_sort Six, Joseph S.
collection PubMed
description Hyperpolarized (83)Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the (83)Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched (83)Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized (83)Kr MRI after krypton inhalation. Different (83)Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T(1) weighted hyperpolarized (83)Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.
format Online
Article
Text
id pubmed-3898897
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-38988972014-01-24 Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr() Six, Joseph S. Hughes-Riley, Theodore Lilburn, David M.L. Dorkes, Alan C. Stupic, Karl F. Shaw, Dominick E. Morris, Peter G. Hall, Ian P. Pavlovskaya, Galina E. Meersmann, Thomas Magn Reson Imaging Original Contribution Hyperpolarized (83)Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the (83)Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched (83)Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized (83)Kr MRI after krypton inhalation. Different (83)Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T(1) weighted hyperpolarized (83)Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. Elsevier 2014-01 /pmc/articles/PMC3898897/ /pubmed/24144493 http://dx.doi.org/10.1016/j.mri.2013.08.007 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Original Contribution
Six, Joseph S.
Hughes-Riley, Theodore
Lilburn, David M.L.
Dorkes, Alan C.
Stupic, Karl F.
Shaw, Dominick E.
Morris, Peter G.
Hall, Ian P.
Pavlovskaya, Galina E.
Meersmann, Thomas
Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title_full Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title_fullStr Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title_full_unstemmed Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title_short Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr()
title_sort pulmonary mri contrast using surface quadrupolar relaxation (square) of hyperpolarized (83)kr()
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898897/
https://www.ncbi.nlm.nih.gov/pubmed/24144493
http://dx.doi.org/10.1016/j.mri.2013.08.007
work_keys_str_mv AT sixjosephs pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT hughesrileytheodore pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT lilburndavidml pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT dorkesalanc pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT stupickarlf pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT shawdominicke pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT morrispeterg pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT hallianp pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT pavlovskayagalinae pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr
AT meersmannthomas pulmonarymricontrastusingsurfacequadrupolarrelaxationsquareofhyperpolarized83kr

Ejemplares similares