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Auditory tracts identified with combined fMRI and diffusion tractography
The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence betwee...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898984/ https://www.ncbi.nlm.nih.gov/pubmed/24051357 http://dx.doi.org/10.1016/j.neuroimage.2013.09.007 |
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author | Javad, Faiza Warren, Jason D. Micallef, Caroline Thornton, John S. Golay, Xavier Yousry, Tarek Mancini, Laura |
author_facet | Javad, Faiza Warren, Jason D. Micallef, Caroline Thornton, John S. Golay, Xavier Yousry, Tarek Mancini, Laura |
author_sort | Javad, Faiza |
collection | PubMed |
description | The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo. |
format | Online Article Text |
id | pubmed-3898984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38989842014-01-24 Auditory tracts identified with combined fMRI and diffusion tractography Javad, Faiza Warren, Jason D. Micallef, Caroline Thornton, John S. Golay, Xavier Yousry, Tarek Mancini, Laura Neuroimage Article The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo. Academic Press 2014-01-01 /pmc/articles/PMC3898984/ /pubmed/24051357 http://dx.doi.org/10.1016/j.neuroimage.2013.09.007 Text en © 2014 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Javad, Faiza Warren, Jason D. Micallef, Caroline Thornton, John S. Golay, Xavier Yousry, Tarek Mancini, Laura Auditory tracts identified with combined fMRI and diffusion tractography |
title | Auditory tracts identified with combined fMRI and diffusion tractography |
title_full | Auditory tracts identified with combined fMRI and diffusion tractography |
title_fullStr | Auditory tracts identified with combined fMRI and diffusion tractography |
title_full_unstemmed | Auditory tracts identified with combined fMRI and diffusion tractography |
title_short | Auditory tracts identified with combined fMRI and diffusion tractography |
title_sort | auditory tracts identified with combined fmri and diffusion tractography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898984/ https://www.ncbi.nlm.nih.gov/pubmed/24051357 http://dx.doi.org/10.1016/j.neuroimage.2013.09.007 |
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