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Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency

There is increasing demand for reconstruction of glottal insufficiency. Several injection materials have been examined for this purpose, but all had limitations, such as poor long-term durability, migration from the injection site, inflammation, granuloma formation, and interference with vocal fold...

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Autores principales: Kwon, Seong Keun, Kim, Hee-Bok, Song, Jae-Jun, Cho, Chang Gun, Park, Seok-Won, Choi, Jong-Sun, Ryu, Junsun, Oh, Se Heang, Lee, Jin Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899012/
https://www.ncbi.nlm.nih.gov/pubmed/24465582
http://dx.doi.org/10.1371/journal.pone.0085512
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author Kwon, Seong Keun
Kim, Hee-Bok
Song, Jae-Jun
Cho, Chang Gun
Park, Seok-Won
Choi, Jong-Sun
Ryu, Junsun
Oh, Se Heang
Lee, Jin Ho
author_facet Kwon, Seong Keun
Kim, Hee-Bok
Song, Jae-Jun
Cho, Chang Gun
Park, Seok-Won
Choi, Jong-Sun
Ryu, Junsun
Oh, Se Heang
Lee, Jin Ho
author_sort Kwon, Seong Keun
collection PubMed
description There is increasing demand for reconstruction of glottal insufficiency. Several injection materials have been examined for this purpose, but all had limitations, such as poor long-term durability, migration from the injection site, inflammation, granuloma formation, and interference with vocal fold vibration due to viscoelastic mismatch. Here, we developed a novel injection material, consisting of polycaprolactone (PCL) microspheres, which exhibits better viscoelasticity than conventional materials, and Pluronic F127 carrier, which decreases the migration of the injection materials. The material was injected into rabbits with glottal insufficiency and compared with the FDA-approved injection material, calcium hydroxylapatite (CaHA). Endoscopic and histological examinations indicated that PCL/Pluronic F127 remained at the injection site with no inflammatory response or granuloma formation, whereas CaHA leaked out and migrated from the injection site. Therefore, vocal fold augmentation was almost completely retained during the 12-month follow-up period in this study. Moreover, induced phonation and high-speed recording of vocal fold vibration showed decreased vocal fold gap area in the PCL/Pluronic F127 group. Our newly developed injection material, PCL/Pluronic F127, permits efficient augmentation of paralyzed vocal fold without complications, a concept that can be applied clinically, as demonstrated by the successful long-term follow-up.
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spelling pubmed-38990122014-01-24 Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency Kwon, Seong Keun Kim, Hee-Bok Song, Jae-Jun Cho, Chang Gun Park, Seok-Won Choi, Jong-Sun Ryu, Junsun Oh, Se Heang Lee, Jin Ho PLoS One Research Article There is increasing demand for reconstruction of glottal insufficiency. Several injection materials have been examined for this purpose, but all had limitations, such as poor long-term durability, migration from the injection site, inflammation, granuloma formation, and interference with vocal fold vibration due to viscoelastic mismatch. Here, we developed a novel injection material, consisting of polycaprolactone (PCL) microspheres, which exhibits better viscoelasticity than conventional materials, and Pluronic F127 carrier, which decreases the migration of the injection materials. The material was injected into rabbits with glottal insufficiency and compared with the FDA-approved injection material, calcium hydroxylapatite (CaHA). Endoscopic and histological examinations indicated that PCL/Pluronic F127 remained at the injection site with no inflammatory response or granuloma formation, whereas CaHA leaked out and migrated from the injection site. Therefore, vocal fold augmentation was almost completely retained during the 12-month follow-up period in this study. Moreover, induced phonation and high-speed recording of vocal fold vibration showed decreased vocal fold gap area in the PCL/Pluronic F127 group. Our newly developed injection material, PCL/Pluronic F127, permits efficient augmentation of paralyzed vocal fold without complications, a concept that can be applied clinically, as demonstrated by the successful long-term follow-up. Public Library of Science 2014-01-22 /pmc/articles/PMC3899012/ /pubmed/24465582 http://dx.doi.org/10.1371/journal.pone.0085512 Text en © 2014 Kwon et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kwon, Seong Keun
Kim, Hee-Bok
Song, Jae-Jun
Cho, Chang Gun
Park, Seok-Won
Choi, Jong-Sun
Ryu, Junsun
Oh, Se Heang
Lee, Jin Ho
Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title_full Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title_fullStr Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title_full_unstemmed Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title_short Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
title_sort vocal fold augmentation with injectable polycaprolactone microspheres/pluronic f127 hydrogel: long-term in vivo study for the treatment of glottal insufficiency
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899012/
https://www.ncbi.nlm.nih.gov/pubmed/24465582
http://dx.doi.org/10.1371/journal.pone.0085512
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