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An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population

BACKGROUND: To date, there are no known estimates of the prevalence of chronic kidney disease within Cambodia, the vast majority of whose citizens live in rural areas with limited access to renal replacement therapy. METHODS: Observational analysis of patients from the Takeo province in Cambodia who...

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Autores principales: Thomas, Bernadette, van Pelt, Maurits, Mehrotra, Rajnish, Robinson-Cohen, Cassianne, LoGerfo, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899115/
https://www.ncbi.nlm.nih.gov/pubmed/24465909
http://dx.doi.org/10.1371/journal.pone.0086123
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author Thomas, Bernadette
van Pelt, Maurits
Mehrotra, Rajnish
Robinson-Cohen, Cassianne
LoGerfo, James
author_facet Thomas, Bernadette
van Pelt, Maurits
Mehrotra, Rajnish
Robinson-Cohen, Cassianne
LoGerfo, James
author_sort Thomas, Bernadette
collection PubMed
description BACKGROUND: To date, there are no known estimates of the prevalence of chronic kidney disease within Cambodia, the vast majority of whose citizens live in rural areas with limited access to renal replacement therapy. METHODS: Observational analysis of patients from the Takeo province in Cambodia who presented to MoPoTsyo, a non-governmental organization, for screening and management of diabetes mellitus between 2010 and 2012 (n = 402; 75% females). Estimated glomerular filtration rate (eGFR) was calculated using the CKD-Epi equation. RESULTS: On average, women were younger, with a higher percentage of hypercholesterolemia but also high-density lipoprotein level. Men had a higher serum creatinine level (1.31 mg/dl) than that of women (1.13 mg/dl) at 95% CI. More than half of all screened patients had a reduced eGFR; 60% (95% CI 55%, 65%) had an eGFR<60 ml/min/1.73 m(2); 54% (49%, 59%) had an eGFR 30–60 ml/min/1.73 m(2), and 5.7% (3.4%, 8.0%) with eGFR 15–30 ml/min/1.73 m(2). Women had a greater prevalence of stage 3 CKD (57% women vs. 47% men) and stage 4 CKD (7.0% vs. 2.0%). The adjusted odds ratio for females compared to males having an eGFR <60 ml/min/1.73 m(2) was 3.19 (95% CI 1.78, 5.43; p value<0.001). Thirty-two percent of patients lost ≥5 ml/min/1.73 m2 eGFR during median follow-up time of 433 days (IQR 462 days) days. CONCLUSIONS: Over one-half of Cambodians with diabetes mellitus had reduced eGFR, implying a point-prevalence of chronic kidney disease of 1.2% in among adult Cambodians within the country. This high burden of kidney disease in a society that lacks universal access to renal replacement therapy underscores the importance of early diagnosis – a largely unmet need in Cambodia.
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spelling pubmed-38991152014-01-24 An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population Thomas, Bernadette van Pelt, Maurits Mehrotra, Rajnish Robinson-Cohen, Cassianne LoGerfo, James PLoS One Research Article BACKGROUND: To date, there are no known estimates of the prevalence of chronic kidney disease within Cambodia, the vast majority of whose citizens live in rural areas with limited access to renal replacement therapy. METHODS: Observational analysis of patients from the Takeo province in Cambodia who presented to MoPoTsyo, a non-governmental organization, for screening and management of diabetes mellitus between 2010 and 2012 (n = 402; 75% females). Estimated glomerular filtration rate (eGFR) was calculated using the CKD-Epi equation. RESULTS: On average, women were younger, with a higher percentage of hypercholesterolemia but also high-density lipoprotein level. Men had a higher serum creatinine level (1.31 mg/dl) than that of women (1.13 mg/dl) at 95% CI. More than half of all screened patients had a reduced eGFR; 60% (95% CI 55%, 65%) had an eGFR<60 ml/min/1.73 m(2); 54% (49%, 59%) had an eGFR 30–60 ml/min/1.73 m(2), and 5.7% (3.4%, 8.0%) with eGFR 15–30 ml/min/1.73 m(2). Women had a greater prevalence of stage 3 CKD (57% women vs. 47% men) and stage 4 CKD (7.0% vs. 2.0%). The adjusted odds ratio for females compared to males having an eGFR <60 ml/min/1.73 m(2) was 3.19 (95% CI 1.78, 5.43; p value<0.001). Thirty-two percent of patients lost ≥5 ml/min/1.73 m2 eGFR during median follow-up time of 433 days (IQR 462 days) days. CONCLUSIONS: Over one-half of Cambodians with diabetes mellitus had reduced eGFR, implying a point-prevalence of chronic kidney disease of 1.2% in among adult Cambodians within the country. This high burden of kidney disease in a society that lacks universal access to renal replacement therapy underscores the importance of early diagnosis – a largely unmet need in Cambodia. Public Library of Science 2014-01-22 /pmc/articles/PMC3899115/ /pubmed/24465909 http://dx.doi.org/10.1371/journal.pone.0086123 Text en © 2014 Thomas et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Thomas, Bernadette
van Pelt, Maurits
Mehrotra, Rajnish
Robinson-Cohen, Cassianne
LoGerfo, James
An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title_full An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title_fullStr An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title_full_unstemmed An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title_short An Estimation of the Prevalence and Progression of Chronic Kidney Disease in a Rural Diabetic Cambodian Population
title_sort estimation of the prevalence and progression of chronic kidney disease in a rural diabetic cambodian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899115/
https://www.ncbi.nlm.nih.gov/pubmed/24465909
http://dx.doi.org/10.1371/journal.pone.0086123
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