Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling

The majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis are pathologically defined by the cleavage, cytoplasmic redistribution and aggregation of TAR DNA binding protein of 43 kDa (TDP-43). To examine the contribution of these potentially toxic mechanisms in vivo...

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Detalles Bibliográficos
Autores principales: D’Alton, Simon, Altshuler, Marcelle, Cannon, Ashley, Dickson, Dennis W., Petrucelli, Leonard, Lewis, Jada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899264/
https://www.ncbi.nlm.nih.gov/pubmed/24466128
http://dx.doi.org/10.1371/journal.pone.0086513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899264/
https://www.ncbi.nlm.nih.gov/pubmed/24466128
http://dx.doi.org/10.1371/journal.pone.0086513

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