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Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women

BACKGROUND: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. METHODS: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers strati...

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Detalles Bibliográficos
Autores principales: Chou, Yu-Ching, Chu, Chi-Hong, Wu, Mei-Hsuan, Hsu, Giu-Cheng, Yang, Tsan, Chou, Wan-Yun, Huang, Hsin-Ping, Lee, Meei-Shyuan, Yu, Cheng-Ping, Yu, Jyh-Cherng, Sun, Chien-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899431/
https://www.ncbi.nlm.nih.gov/pubmed/21705842
http://dx.doi.org/10.2188/jea.JE20100188
Descripción
Sumario:BACKGROUND: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. METHODS: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B(6) was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. RESULTS: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B(6) intake were 0.78 (95% CI, 0.64–2.52) and 0.64 (0.26–0.92), respectively. In addition, higher vitamin B(6) intake was associated with a significantly lower risk of developing ER-negative breast tumors. CONCLUSIONS: Our findings suggest that higher intake of vitamin B(6) is associated with a reduction in breast cancer risk, particularly ER-negative tumors.