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Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women

BACKGROUND: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. METHODS: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers strati...

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Autores principales: Chou, Yu-Ching, Chu, Chi-Hong, Wu, Mei-Hsuan, Hsu, Giu-Cheng, Yang, Tsan, Chou, Wan-Yun, Huang, Hsin-Ping, Lee, Meei-Shyuan, Yu, Cheng-Ping, Yu, Jyh-Cherng, Sun, Chien-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899431/
https://www.ncbi.nlm.nih.gov/pubmed/21705842
http://dx.doi.org/10.2188/jea.JE20100188
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author Chou, Yu-Ching
Chu, Chi-Hong
Wu, Mei-Hsuan
Hsu, Giu-Cheng
Yang, Tsan
Chou, Wan-Yun
Huang, Hsin-Ping
Lee, Meei-Shyuan
Yu, Cheng-Ping
Yu, Jyh-Cherng
Sun, Chien-An
author_facet Chou, Yu-Ching
Chu, Chi-Hong
Wu, Mei-Hsuan
Hsu, Giu-Cheng
Yang, Tsan
Chou, Wan-Yun
Huang, Hsin-Ping
Lee, Meei-Shyuan
Yu, Cheng-Ping
Yu, Jyh-Cherng
Sun, Chien-An
author_sort Chou, Yu-Ching
collection PubMed
description BACKGROUND: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. METHODS: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B(6) was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. RESULTS: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B(6) intake were 0.78 (95% CI, 0.64–2.52) and 0.64 (0.26–0.92), respectively. In addition, higher vitamin B(6) intake was associated with a significantly lower risk of developing ER-negative breast tumors. CONCLUSIONS: Our findings suggest that higher intake of vitamin B(6) is associated with a reduction in breast cancer risk, particularly ER-negative tumors.
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spelling pubmed-38994312014-02-04 Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women Chou, Yu-Ching Chu, Chi-Hong Wu, Mei-Hsuan Hsu, Giu-Cheng Yang, Tsan Chou, Wan-Yun Huang, Hsin-Ping Lee, Meei-Shyuan Yu, Cheng-Ping Yu, Jyh-Cherng Sun, Chien-An J Epidemiol Original Article BACKGROUND: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis. METHODS: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B(6) was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. RESULTS: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B(6) intake were 0.78 (95% CI, 0.64–2.52) and 0.64 (0.26–0.92), respectively. In addition, higher vitamin B(6) intake was associated with a significantly lower risk of developing ER-negative breast tumors. CONCLUSIONS: Our findings suggest that higher intake of vitamin B(6) is associated with a reduction in breast cancer risk, particularly ER-negative tumors. Japan Epidemiological Association 2011-09-05 /pmc/articles/PMC3899431/ /pubmed/21705842 http://dx.doi.org/10.2188/jea.JE20100188 Text en © 2011 Japan Epidemiological Association. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Chou, Yu-Ching
Chu, Chi-Hong
Wu, Mei-Hsuan
Hsu, Giu-Cheng
Yang, Tsan
Chou, Wan-Yun
Huang, Hsin-Ping
Lee, Meei-Shyuan
Yu, Cheng-Ping
Yu, Jyh-Cherng
Sun, Chien-An
Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title_full Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title_fullStr Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title_full_unstemmed Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title_short Dietary Intake of Vitamin B(6) and Risk of Breast Cancer in Taiwanese Women
title_sort dietary intake of vitamin b(6) and risk of breast cancer in taiwanese women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899431/
https://www.ncbi.nlm.nih.gov/pubmed/21705842
http://dx.doi.org/10.2188/jea.JE20100188
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