The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors

Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ER-α36 mediates non-genomic signaling and is involved in genomic signaling of other ERs. Re...

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Autores principales: Gu, Yu, Chen, Tianxiang, López, Elena, Wu, Weizhu, Wang, Xiangdong, Cao, Jiang, Teng, Lisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899443/
https://www.ncbi.nlm.nih.gov/pubmed/24447535
http://dx.doi.org/10.1186/1479-5876-12-16
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author Gu, Yu
Chen, Tianxiang
López, Elena
Wu, Weizhu
Wang, Xiangdong
Cao, Jiang
Teng, Lisong
author_facet Gu, Yu
Chen, Tianxiang
López, Elena
Wu, Weizhu
Wang, Xiangdong
Cao, Jiang
Teng, Lisong
author_sort Gu, Yu
collection PubMed
description Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ER-α36 mediates non-genomic signaling and is involved in genomic signaling of other ERs. Recently ER-α36 is found to play a critical role in the development of estrogen-dependent cancers and endocrine resistance of breast cancer. The present article overviews and updates the biological nature and function of ER-α36, potential interaction of ER-α36 with other estrogen receptors and growth factor receptors, intracellular signaling pathways, potential mechanism by which ER-α36 may play an important role in the development of tumor resistance to endocrine therapies.
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spelling pubmed-38994432014-01-24 The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors Gu, Yu Chen, Tianxiang López, Elena Wu, Weizhu Wang, Xiangdong Cao, Jiang Teng, Lisong J Transl Med Review Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ER-α36 mediates non-genomic signaling and is involved in genomic signaling of other ERs. Recently ER-α36 is found to play a critical role in the development of estrogen-dependent cancers and endocrine resistance of breast cancer. The present article overviews and updates the biological nature and function of ER-α36, potential interaction of ER-α36 with other estrogen receptors and growth factor receptors, intracellular signaling pathways, potential mechanism by which ER-α36 may play an important role in the development of tumor resistance to endocrine therapies. BioMed Central 2014-01-21 /pmc/articles/PMC3899443/ /pubmed/24447535 http://dx.doi.org/10.1186/1479-5876-12-16 Text en Copyright © 2014 Gu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gu, Yu
Chen, Tianxiang
López, Elena
Wu, Weizhu
Wang, Xiangdong
Cao, Jiang
Teng, Lisong
The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title_full The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title_fullStr The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title_full_unstemmed The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title_short The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
title_sort therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899443/
https://www.ncbi.nlm.nih.gov/pubmed/24447535
http://dx.doi.org/10.1186/1479-5876-12-16
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