Angiopoietin-Like Proteins: A Comprehensive Look

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological pr...

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Detalles Bibliográficos
Autor principal: Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899539/
https://www.ncbi.nlm.nih.gov/pubmed/24478758
http://dx.doi.org/10.3389/fendo.2014.00004
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author Santulli, Gaetano
author_facet Santulli, Gaetano
author_sort Santulli, Gaetano
collection PubMed
description Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.
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spelling pubmed-38995392014-01-29 Angiopoietin-Like Proteins: A Comprehensive Look Santulli, Gaetano Front Endocrinol (Lausanne) Endocrinology Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL. Frontiers Media S.A. 2014-01-23 /pmc/articles/PMC3899539/ /pubmed/24478758 http://dx.doi.org/10.3389/fendo.2014.00004 Text en Copyright © 2014 Santulli. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Santulli, Gaetano
Angiopoietin-Like Proteins: A Comprehensive Look
title Angiopoietin-Like Proteins: A Comprehensive Look
title_full Angiopoietin-Like Proteins: A Comprehensive Look
title_fullStr Angiopoietin-Like Proteins: A Comprehensive Look
title_full_unstemmed Angiopoietin-Like Proteins: A Comprehensive Look
title_short Angiopoietin-Like Proteins: A Comprehensive Look
title_sort angiopoietin-like proteins: a comprehensive look
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899539/
https://www.ncbi.nlm.nih.gov/pubmed/24478758
http://dx.doi.org/10.3389/fendo.2014.00004
work_keys_str_mv AT santulligaetano angiopoietinlikeproteinsacomprehensivelook

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