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Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles

Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important f...

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Autores principales: Zhou, Ziyou, Bedwell, Gregory J., Li, Rui, Prevelige, Peter E., Gupta, Arunava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899596/
https://www.ncbi.nlm.nih.gov/pubmed/24452221
http://dx.doi.org/10.1038/srep03832
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author Zhou, Ziyou
Bedwell, Gregory J.
Li, Rui
Prevelige, Peter E.
Gupta, Arunava
author_facet Zhou, Ziyou
Bedwell, Gregory J.
Li, Rui
Prevelige, Peter E.
Gupta, Arunava
author_sort Zhou, Ziyou
collection PubMed
description Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important for the controlled synthesis of inorganic nanoparticles inside VLP and rational assembly of ordered VLP-based hierarchical nanostructures. We have investigated in detail the formation mechanism and growth kinetics of semiconducting nanocrystals confined inside genetically engineered bacteriophage P22 VLP using semiconducting CdS as a prototypical example. The selective nucleation and growth of CdS at the engineered sites is found to be uniform during the early stage, followed by a more stochastic growth process. Furthermore, kinetic studies reveal that the presence of an engineered biotemplate helps in significantly retarding the reaction rate. These findings provide guidance for the controlled synthesis of a wide range of other inorganic materials confined inside VLP, and are of practical importance for the rational design of VLP-based hierarchical nanostuctures.
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spelling pubmed-38995962014-01-24 Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles Zhou, Ziyou Bedwell, Gregory J. Li, Rui Prevelige, Peter E. Gupta, Arunava Sci Rep Article Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important for the controlled synthesis of inorganic nanoparticles inside VLP and rational assembly of ordered VLP-based hierarchical nanostructures. We have investigated in detail the formation mechanism and growth kinetics of semiconducting nanocrystals confined inside genetically engineered bacteriophage P22 VLP using semiconducting CdS as a prototypical example. The selective nucleation and growth of CdS at the engineered sites is found to be uniform during the early stage, followed by a more stochastic growth process. Furthermore, kinetic studies reveal that the presence of an engineered biotemplate helps in significantly retarding the reaction rate. These findings provide guidance for the controlled synthesis of a wide range of other inorganic materials confined inside VLP, and are of practical importance for the rational design of VLP-based hierarchical nanostuctures. Nature Publishing Group 2014-01-23 /pmc/articles/PMC3899596/ /pubmed/24452221 http://dx.doi.org/10.1038/srep03832 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Zhou, Ziyou
Bedwell, Gregory J.
Li, Rui
Prevelige, Peter E.
Gupta, Arunava
Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title_full Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title_fullStr Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title_full_unstemmed Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title_short Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
title_sort formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899596/
https://www.ncbi.nlm.nih.gov/pubmed/24452221
http://dx.doi.org/10.1038/srep03832
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