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Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles
Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899596/ https://www.ncbi.nlm.nih.gov/pubmed/24452221 http://dx.doi.org/10.1038/srep03832 |
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author | Zhou, Ziyou Bedwell, Gregory J. Li, Rui Prevelige, Peter E. Gupta, Arunava |
author_facet | Zhou, Ziyou Bedwell, Gregory J. Li, Rui Prevelige, Peter E. Gupta, Arunava |
author_sort | Zhou, Ziyou |
collection | PubMed |
description | Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important for the controlled synthesis of inorganic nanoparticles inside VLP and rational assembly of ordered VLP-based hierarchical nanostructures. We have investigated in detail the formation mechanism and growth kinetics of semiconducting nanocrystals confined inside genetically engineered bacteriophage P22 VLP using semiconducting CdS as a prototypical example. The selective nucleation and growth of CdS at the engineered sites is found to be uniform during the early stage, followed by a more stochastic growth process. Furthermore, kinetic studies reveal that the presence of an engineered biotemplate helps in significantly retarding the reaction rate. These findings provide guidance for the controlled synthesis of a wide range of other inorganic materials confined inside VLP, and are of practical importance for the rational design of VLP-based hierarchical nanostuctures. |
format | Online Article Text |
id | pubmed-3899596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38995962014-01-24 Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles Zhou, Ziyou Bedwell, Gregory J. Li, Rui Prevelige, Peter E. Gupta, Arunava Sci Rep Article Engineered virus-like particles (VLP) are attractive for fabricating nanostructured materials for applications in diverse areas such as catalysis, drug delivery, biomedicine, composites, etc. Basic understanding of the interaction between the inorganic guest and biomolecular host is thus important for the controlled synthesis of inorganic nanoparticles inside VLP and rational assembly of ordered VLP-based hierarchical nanostructures. We have investigated in detail the formation mechanism and growth kinetics of semiconducting nanocrystals confined inside genetically engineered bacteriophage P22 VLP using semiconducting CdS as a prototypical example. The selective nucleation and growth of CdS at the engineered sites is found to be uniform during the early stage, followed by a more stochastic growth process. Furthermore, kinetic studies reveal that the presence of an engineered biotemplate helps in significantly retarding the reaction rate. These findings provide guidance for the controlled synthesis of a wide range of other inorganic materials confined inside VLP, and are of practical importance for the rational design of VLP-based hierarchical nanostuctures. Nature Publishing Group 2014-01-23 /pmc/articles/PMC3899596/ /pubmed/24452221 http://dx.doi.org/10.1038/srep03832 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Zhou, Ziyou Bedwell, Gregory J. Li, Rui Prevelige, Peter E. Gupta, Arunava Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title | Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title_full | Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title_fullStr | Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title_full_unstemmed | Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title_short | Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
title_sort | formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899596/ https://www.ncbi.nlm.nih.gov/pubmed/24452221 http://dx.doi.org/10.1038/srep03832 |
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