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BACE1 activity regulates cell surface contactin-2 levels

BACKGROUND: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-med...

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Detalles Bibliográficos
Autores principales:	Gautam, Vivek, D’Avanzo, Carla, Hebisch, Matthias, Kovacs, Dora M, Kim, Doo Yeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899608/ https://www.ncbi.nlm.nih.gov/pubmed/24405708 http://dx.doi.org/10.1186/1750-1326-9-4

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