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Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study
OBJECTIVE: Unsuspected idiopathic intracranial hypertension (IIH) is found in a significant minority of patients attending clinics with named headache syndromes, if it is specifically sought out. Chronic fatigue syndrome is frequently associated with headache. Could the same be true of chronic fatig...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899735/ https://www.ncbi.nlm.nih.gov/pubmed/24475346 http://dx.doi.org/10.1177/2042533313507920 |
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author | Higgins, Nicholas Pickard, John Lever, Andrew |
author_facet | Higgins, Nicholas Pickard, John Lever, Andrew |
author_sort | Higgins, Nicholas |
collection | PubMed |
description | OBJECTIVE: Unsuspected idiopathic intracranial hypertension (IIH) is found in a significant minority of patients attending clinics with named headache syndromes, if it is specifically sought out. Chronic fatigue syndrome is frequently associated with headache. Could the same be true of chronic fatigue? Moreover, there are striking similarities between the two conditions. Could they be related? Attempting to answer these questions, we describe the results of a change in clinical practice aimed at capturing patients with chronic fatigue who might have IIH. DESIGN: Cross-sectional. SETTING: Hospital outpatient and radiology departments. PARTICIPANTS: Patients attending a specialist clinic with chronic fatigue syndrome and headache who had lumbar puncture to exclude raised intracranial pressure. MAIN OUTCOME MEASURES: Intracranial pressure measured at lumbar puncture and the effect on headache of cerebrospinal fluid drainage. RESULTS: Mean cerebrospinal fluid pressure was 19 cm H(2)O (range 12–41 cm H(2)O). Four patients fulfilled the criteria for IIH. Thirteen others did not have pressures high enough to diagnose IIH but still reported an improvement in headache after drainage of cerebrospinal fluid. Some patients also volunteered an improvement in other symptoms, including fatigue. No patient had any clinical signs of raised intracranial pressure. CONCLUSIONS: An unknown, but possibly substantial, minority of patients with chronic fatigue syndrome may actually have IIH. An unknown, but much larger, proportion of patients with chronic fatigue syndrome do not have IIH by current criteria but respond to lumbar puncture in the same way as patients who do. This suggests that the two conditions may be related. |
format | Online Article Text |
id | pubmed-3899735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-38997352014-01-28 Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study Higgins, Nicholas Pickard, John Lever, Andrew JRSM Short Rep Research OBJECTIVE: Unsuspected idiopathic intracranial hypertension (IIH) is found in a significant minority of patients attending clinics with named headache syndromes, if it is specifically sought out. Chronic fatigue syndrome is frequently associated with headache. Could the same be true of chronic fatigue? Moreover, there are striking similarities between the two conditions. Could they be related? Attempting to answer these questions, we describe the results of a change in clinical practice aimed at capturing patients with chronic fatigue who might have IIH. DESIGN: Cross-sectional. SETTING: Hospital outpatient and radiology departments. PARTICIPANTS: Patients attending a specialist clinic with chronic fatigue syndrome and headache who had lumbar puncture to exclude raised intracranial pressure. MAIN OUTCOME MEASURES: Intracranial pressure measured at lumbar puncture and the effect on headache of cerebrospinal fluid drainage. RESULTS: Mean cerebrospinal fluid pressure was 19 cm H(2)O (range 12–41 cm H(2)O). Four patients fulfilled the criteria for IIH. Thirteen others did not have pressures high enough to diagnose IIH but still reported an improvement in headache after drainage of cerebrospinal fluid. Some patients also volunteered an improvement in other symptoms, including fatigue. No patient had any clinical signs of raised intracranial pressure. CONCLUSIONS: An unknown, but possibly substantial, minority of patients with chronic fatigue syndrome may actually have IIH. An unknown, but much larger, proportion of patients with chronic fatigue syndrome do not have IIH by current criteria but respond to lumbar puncture in the same way as patients who do. This suggests that the two conditions may be related. SAGE Publications 2013-11-21 /pmc/articles/PMC3899735/ /pubmed/24475346 http://dx.doi.org/10.1177/2042533313507920 Text en © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav http://creativecommons.org/licenses/by-nc/2.0/ This is an open-access article distributed under the terms of the Creative Commons Non-commercial Attribution License (http://creativecommons.org/licenses/by-nc/2.0/), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Higgins, Nicholas Pickard, John Lever, Andrew Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study |
title | Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
title_full | Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
title_fullStr | Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
title_full_unstemmed | Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
title_short | Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
title_sort | lumbar puncture, chronic fatigue syndrome and idiopathic intracranial
hypertension: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899735/ https://www.ncbi.nlm.nih.gov/pubmed/24475346 http://dx.doi.org/10.1177/2042533313507920 |
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